Association of low plasma antioxidant levels with all-cause mortality and coronary events in healthy middle-aged men from France and Northern Ireland in the PRIME study.

ABSTRACT:

Background

The main underlying risk factors associated with coronary heart disease (CHD) are modifiable and oxidative injury and systemic inflammatory damage represent key aetiological factors associated with the development and progression of CHD and premature mortality.

Objective

To examine associations of plasma antioxidant status with all-cause mortality and fatal or non-fatal cardiovascular events.

Design

The PRIME study prospectively evaluated 9709 men aged 50-59 years between 1991 and 1993 in Northern Ireland and France who were free of CHD at recruitment and followed annually for deaths and cardiovascular events for 10 years. Serum concentrations of vitamin C, retinol, two forms of vitamin E (α- and γ-tocopherol) and six carotenoids were quantified by high-per

SUBMITTER: McKay GJ 

PROVIDER: S-EPMC8275518 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature