Predictive performance of parent-metabolite population pharmacokinetic models of (S)-ketamine in healthy volunteers.

ABSTRACT:

Purpose

The recent repurposing of ketamine as treatment for pain and depression has increased the need for accurate population pharmacokinetic (PK) models to inform the design of new clinical trials. Therefore, the objectives of this study were to externally validate available PK models on (S)-(nor)ketamine concentrations with in-house data and to improve the best performing model when necessary.

Methods

Based on predefined criteria, five models were selected from literature. Data of two previously performed clinical trials on (S)-ketamine administration in healthy volunteers were available for validation. The predictive performances of the selected models were compared through visual predictive checks (VPCs) and calculation of the (root) mean (square) prediction errors (ME

SUBMITTER: Otto ME 

PROVIDER: S-EPMC8275530 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature