Multiomic analysis of Schistosoma mansoni reveals unique expression profiles in cercarial heads and tails.

ABSTRACT: Schistosomes require both molluscan and mammalian hosts for development. The larval cercaria exits the snail host and swims to identify and invade the mammalian host. The cercaria has two macrostructures, the head and the tail. The head invades the host, where it matures into an adult worm. The tail is lost after host invasion. Translation in the cercaria differs in each macrostructure, with higher levels of translation in the cercarial tail and little to no translational activity in the cercarial head. We compared the transcriptome and proteome of the cercarial head and tail and observed stark differences between the two macrostructures. We identified unique and differentially expressed transcripts and proteins, including ribosomal components expressed in higher levels in tails than in he

SUBMITTER: Hagerty JR 

PROVIDER: S-EPMC8275615 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature