Application across species of a one health approach to liquid sample handling for respiratory based -omics analysis.

ABSTRACT: Airway inflammation is highly prevalent in horses, with the majority of non-infectious cases being defined as equine asthma. Currently, cytological analysis of airway derived samples is the principal method of assessing lower airway inflammation. Samples can be obtained by tracheal wash (TW) or by lavage of the lower respiratory tract (bronchoalveolar lavage (BAL) fluid; BALF). Although BALF cytology carries significant diagnostic advantages over TW cytology for the diagnosis of equine asthma, sample acquisition is invasive, making it prohibitive for routine and sequential screening of airway health. However, recent technological advances in sample collection and processing have made it possible to determine whether a wider range of analyses might be applied to TW samples. Considering that

SUBMITTER: Karagianni AE 

PROVIDER: S-EPMC8275668 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature