Integrative biology defines novel biomarkers of resistance to strongylid infection in horses.

ABSTRACT: The widespread failure of anthelmintic drugs against nematodes of veterinary interest requires novel control strategies. Selective treatment of the most susceptible individuals could reduce drug selection pressure but requires appropriate biomarkers of the intrinsic susceptibility potential. To date, this has been missing in livestock species. Here, we selected Welsh ponies with divergent intrinsic susceptibility (measured by their egg excretion levels) to cyathostomin infection and found that their divergence was sustained across a 10-year time window. Using this unique set of individuals, we monitored variations in their blood cell populations, plasma metabolites and faecal microbiota over a grazing season to isolate core differences between their respective responses under worm-free or

SUBMITTER: Salle G 

PROVIDER: S-EPMC8275762 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature