Emerging mutation in SARS-CoV-2 spike: Widening distribution over time in different geographic areas.

ABSTRACT: Recently, differences in mortality rates of COVID-19 in different geographic areas have become an important subject of research because these different mortality rates appear to be associated with mutations that appeared in SARS-CoV-2. The part of the viral body called the spike protein plays a critical role in the viral attachment and entry of the virus into the host cell. Accordingly, we hypothesized that mutations in this area will affect viral infectivity. A total of 193 sequences of spike SARS-CoV-2 were randomly retrieved from five different geographic areas and collection dates (from December 2019 until July 2020). Multiple sequence alignment for mutation and phylogenetic analyses was conducted using Bioedit, UniProt, and MEGA X. We found 169 total mutations with 37 different mutati

SUBMITTER: Ysrafil Y 

PROVIDER: S-EPMC8275844 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature