Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue.

ABSTRACT: Recent studies demonstrate that adaptations to white adipose tissue (WAT) are important components of the beneficial effects of exercise training on metabolic health. Exercise training favorably alters the phenotype of subcutaneous inguinal WAT (iWAT) in male mice, including decreasing fat mass, improving mitochondrial function, inducing beiging, and stimulating the secretion of adipokines. In this study, we find that despite performing more voluntary wheel running compared with males, these adaptations do not occur in the iWAT of female mice. Consistent with sex-specific adaptations, we report that mRNA expression of androgen receptor coactivators is upregulated in iWAT from trained male mice and that testosterone treatment of primary adipocytes derived from the iWAT of male, but not fema

SUBMITTER: Nigro P 

PROVIDER: S-EPMC8275891 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature