Vitamin D₃ decreases TNF-α-induced inflammation in lung epithelial cells through a reduction in mitochondrial fission and mitophagy.

ABSTRACT: Previous work has shown an association between vitamin D₃ deficiency and an increased risk for acquiring various inflammatory diseases. Vitamin D₃ can reduce morbidity and mortality in these patients via different mechanisms. Lung inflammation is an important event in the initiation and development of respiratory disorders. However, the anti-inflammatory effects of vitamin D₃ and the underlying mechanisms remained to be determined. The purpose of this study was to examine the effects and mechanisms of action of vitamin D₃ (Vit. D) on the expression of intercellular adhesion molecule-1 (ICAM-1) in vitro and in vivo with or without tumor necrosis factor α (TNF-α) treatment. Pretreatment with Vit. D reduced the expression of ICAM-1 and leukocyte adh

SUBMITTER: Chen YC 

PROVIDER: S-EPMC8275919 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature