D-dimer and Death in Critically Ill Patients With Coronavirus Disease 2019.

ABSTRACT:

Objectives

Hypercoagulability may be a key mechanism for acute organ injury and death in patients with severe coronavirus disease 2019, but the relationship between elevated plasma levels of d-dimer, a biomarker of coagulation activation, and mortality has not been rigorously studied. We examined the independent association between d-dimer and death in critically ill patients with coronavirus disease 2019.

Design

Multicenter cohort study.

Setting

ICUs at 68 hospitals across the United States.

Patients

Critically ill adults with coronavirus disease 2019 admitted to ICUs between March 4, 2020, and May 25, 2020, with a measured d-dimer concentration on ICU day 1 or 2.

Interventions

None.

Measurements and main results

The primary exposure was the high

SUBMITTER: Short SAP 

PROVIDER: S-EPMC8275993 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature