Using Zebrafish to Elucidate Glial-Vascular Interactions During CNS Development.

ABSTRACT: An emerging area of interest in Neuroscience is the cellular relationship between glia and blood vessels, as many of the presumptive support roles of glia require an association with the vasculature. These interactions are best studied in vivo and great strides have been made using mice to longitudinally image glial-vascular interactions. However, these methods are cumbersome for developmental studies, which could benefit from a more accessible system. Zebrafish (Danio rerio) are genetically tractable vertebrates, and given their translucency, are readily amenable for daily live imaging studies. We set out to examine whether zebrafish glia have conserved traits with mammalian glia regarding their ability to interact with and maintain the developing brain vasculature. We utili

SUBMITTER: Umans RA 

PROVIDER: S-EPMC8276133 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature