Impact of Ivabradine on renal function in septic patient with early renal impairment

ABSTRACT:

Background

Acute kidney injury (AKI) with sepsis increases mortality significantly. The pathophysiology of AKI during sepsis is complex and multifactorial. Lower heart rate is associated with better survival in patients with multiple organ dysfunction syndrome (MODS), a disease mostly caused by sepsis. In our study, we hypnotized that use of ivardrabine as heart rate reducing agent in septic patient with renal impairment may improve renal function.

Results

Fifty patients with sepsis with early renal impairment were divided in 1: 1 ratio to receive Ivabradine (group I) or not (group C). The average age of the included patients was almost 45 years, chest disorders were the main cause of sepsis in both groups. There were statistically significant differences between both gro

SUBMITTER: Sobhy A 

PROVIDER: S-EPMC8276210 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature