A novel ferroptosis-related genes model for prognosis prediction of lung adenocarcinoma.

ABSTRACT:

Background

Ferroptosis is a newly discovered form of cell death characterized by iron-dependent lipid peroxidation. This study aims to investigate the potential correlation between ferroptosis and the prognosis of lung adenocarcinoma (LUAD).

Methods

RNA-seq data were collected from the LUAD dataset of The Cancer Genome Atlas (TCGA) database. Based on ferroptosis-related genes, differentially expressed genes (DEGs) between LUAD and paracancerous specimens were identified. The univariate Cox regression analysis was performed to screen key genes associated with the prognosis of LUAD. LUAD patients were divided into the training set and validation set. Then, we screened out key genes and built a prognostic prediction model involving 5 genes using the least absolute shrinkage and

SUBMITTER: Li F 

PROVIDER: S-EPMC8276441 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature