Assessment of auditory and vestibular damage in a mouse model after single and triple blast exposures.

ABSTRACT: The use of explosive devices in war and terrorism has increased exposure to concussive blasts among both military personnel and civilians, which can cause permanent hearing and balance deficits that adversely affect survivors' quality of life. Significant knowledge gaps on the underlying etiology of blast-induced hearing loss and balance disorders remain, especially with regard to the effect of blast exposure on the vestibular system, the impact of multiple blast exposures, and long-term recovery. To address this, we investigated the effects of blast exposure on the inner ear using a mouse model in conjunction with a high-fidelity blast simulator. Anesthetized animals were subjected to single or triple blast exposures, and physiological measurements and tissue were collected over the cours

SUBMITTER: Mao B 

PROVIDER: S-EPMC8276524 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature