Computational and network pharmacology studies of <i>Phyllanthus emblica</i> to tackle SARS-CoV-2.

ABSTRACT:

Background

Since December 2019, SARS-CoV-2 had been a significant threat globally, which has accounted for about two million deaths. Several types of research are undergoing and have reported the significant role of repurposing existing drugs and natural lead in the treatment of COVID-19. The plant Phyllanthus emblica (Synonym-Emblica officinalis) (Euphorbiaceae) is a rich source of vitamin C, and its use as an antiviral agent has been well established.

Purpose

The present study was undertaken to investigate the potency of the several components of Phyllanthus emblica against three protein targets of 2019-nCoV viz. NSP15 endoribonuclease, main protease, and receptor binding domain of prefusion spike protein using molecular docking and dynamics studies.

SUBMITTER: Chikhale RV 

PROVIDER: S-EPMC8276571 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature