Detergent-free systems for structural studies of membrane proteins.

ABSTRACT: Membrane proteins play vital roles in living organisms, serving as targets for most currently prescribed drugs. Membrane protein structural biology aims to provide accurate structural information to understand their mechanisms of action. The advance of membrane protein structural biology has primarily relied on detergent-based methods over the past several decades. However, detergent-based approaches have significant drawbacks because detergents often damage the native protein-lipid interactions, which are often crucial for maintaining the natural structure and function of membrane proteins. Detergent-free methods recently have emerged as alternatives with a great promise, e.g. for high-resolution structure determinations of membrane proteins in their native cell membrane lipid environment

SUBMITTER: Guo Y 

PROVIDER: S-EPMC8276625 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature