Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis.

ABSTRACT: Early life, including the establishment of the intestinal microbiome, represents a critical window of growth and development. Postnatal factors affecting the microbiome, including mode of delivery, feeding type, and antibiotic exposure have been widely investigated, but questions remain regarding the influence of exposures in utero on infant gut microbiome assembly. This systematic review aimed to synthesize evidence on exposures before birth, which affect the early intestinal microbiome. Five databases were searched in August 2019 for studies exploring pre-pregnancy or pregnancy 'exposure' data in relation to the infant microbiome. Of 1,441 publications identified, 76 were included. Factors reported influencing microbiome composition and diversity included maternal antibiotic and p

SUBMITTER: Grech A 

PROVIDER: S-EPMC8276657 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature