Purinergic Signaling: Impact of GPCR Structures on Rational Drug Design.

ABSTRACT: The purinergic signaling system includes membrane-bound receptors for extracellular purines and pyrimidines, and enzymes/transporters that regulate receptor activation by endogenous agonists. Receptors include: adenosine (A₁ , A_2A , A_2B, and A₃ ) and P2Y (P2Y₁ , P2Y₂ , P2Y₄ , P2Y₆ , P2Y₁₁ , P2Y₁₂ , P2Y₁₃ , and P2Y₁₄ ) receptors (all GPCRs), as well as P2X receptors (ion channels). Receptor activation, especially accompanying physiological stress or damage, creates a temporal sequence of signaling to counteract this stress and either mobilize (P2Rs) or suppress (ARs) immune responses. Thus, modulation of this large signaling family has broad potential for treat

SUBMITTER: Salmaso V 

PROVIDER: S-EPMC8276773 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature