The evolving role of immunotherapy in prostate cancer.

ABSTRACT:

Purpose of review

In recent clinical trials, immunotherapeutic agents have demonstrated promising results for the treatment of prostate cancer. This review discusses emerging immunotherapies for prostate cancer and their evolving role in sequencing and combination therapy.

Recent findings

Therapeutic vaccines including PROSTVAC and DCVAC/PCa have completed promising phase 2 trials for the treatment of prostate cancer and phase 3 trials are underway. Recent evidence supports a synergistic relationship between immunotherapy agents themselves, antiandrogens and with cytotoxic chemotherapy. Prostate cancer patients with good prognostic factors, such as minimal disease burden, appear to achieve the optimal benefit from immunotherapy.

Summary

Therapeutic cancer vaccines and

SUBMITTER: Cordes LM 

PROVIDER: S-EPMC8276828 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature