Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals.

ABSTRACT: The SARS-CoV-2 spike protein Q677P/H mutation and furin cleavage site (FCS) have been shown to affect cell tropism and virus transmissibility. Here, we analyzed the frequency of Q677P/H and FCS point mutations in 1,144,793 human and 1042 animal spike protein sequences and from those of the emergent variants B.1.1.7, B.1.351, P.1, B.1.429 + B.1.427, and B.1.525, which were deposited in the database of the GISAID Initiative. Different genetic polymorphisms, particularly P681H and A688V, were detected in the FCS, mainly in human isolates, and otherwise, only pangolin and bat sequences had these mutations. Multiple FCS amino acid deletions such as Δ⁶⁸⁰SPRRA⁶⁸⁴ and Δ⁶⁸⁵RSVA⁶⁸⁸ were only detected in eight and four human isolates, respectively. Surprisi

SUBMITTER: Nagy A 

PROVIDER: S-EPMC8276844 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature