A fluorescent target-guided Paal-Knorr reaction.

ABSTRACT: It has become increasingly apparent that high-diversity chemical reactions play a significant role in the discovery of bioactive small molecules. Here, we describe an expanse of this paradigm, combining a 'target-guided synthesis' concept with Paal-Knorr chemistry applied to the preparation of fluorescent ligands for human prostaglandin-endoperoxide synthase (COX-2).

SUBMITTER: Wagh SB 

PROVIDER: S-EPMC8276889 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature