The clinicopathologic significance of Tks5 expression of peritoneal mesothelial cells in gastric cancer patients.

ABSTRACT:

Background

Gastric cancer (GC) patients frequently develop peritoneal metastasis. Recently, it has been reported that peritoneal mesothelial cells (PMCs) activated by GC cells acquire a migratory capacity and promote GC cell invasion. The invasiveness of PMCs reportedly depends on the activity of Tks5, an adaptor protein required for invadopodia formation. However, the relationship between clinicopathologic features and Tks5 expression in PMCs has been poorly documented. In this study, we evaluated the clinicopathologic significance of the Tks5 expression of PMCs in GC patients.

Materials and methods

A total of 110 GC patients who underwent gastrectomy were enrolled in this study. Tks5 expressions in PMCs from the greater omentum, lesser omentum and retroperitoneum were eval

SUBMITTER: Sugimoto A 

PROVIDER: S-EPMC8277061 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature