The Spectrum of Mechanism-Oriented Models and Methods for Explanations of Biological Phenomena.

ABSTRACT: Developing and improving mechanism-oriented computational models to better explain biological phenomena is a dynamic and expanding frontier. As the complexity of targeted phenomena has increased, so too has the diversity in methods and terminologies, often at the expense of clarity, which can make reproduction challenging, even problematic. To encourage improved semantic and methodological clarity, we describe the spectrum of Mechanism-oriented Models being used to develop explanations of biological phenomena. We cluster explanations of phenomena into three broad groups. We then expand them into seven workflow-related model types having distinguishable features. We name each type and illustrate with examples drawn from the literature. These model types may contribute to the foundation of a

SUBMITTER: Hunt CA 

PROVIDER: S-EPMC8277120 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature