Association of Genetically Predicted Serum Estradiol With Risk of Thromboembolism in Men: A Mendelian Randomization Study.

ABSTRACT:

Context

An association was recently reported between genetic markers related to high testosterone and increased risk of thromboembolism in men, but a possible causal role of estradiol for risk of thromboembolism in men remains unknown.

Objective

This work aimed to determine whether endogenous estradiol has a causal role in thromboembolism in men.

Methods

A 2-sample mendelian randomization study using gene-based genetic instruments assessed the association between endogenous estradiol genetically predicted by 22 variants in the aromatase CYP19A1 gene region and the risk of thromboembolism (5815 cases) in 170 593 unrelated men of White ancestry in the UK Biobank. The main outcome measure included thromboembolism based on self-reports, hospital episodes, and death.

Re

SUBMITTER: Nethander M 

PROVIDER: S-EPMC8277207 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature