Gut microbiota-derived metabolites and risk of coronary artery disease: a prospective study among US men and women.

ABSTRACT:

Background

Accumulating evidence has suggested that human gut microbiota metabolize certain dietary compounds and subsequently produce bioactive metabolites that may exert beneficial or harmful effects on coronary artery disease (CAD) risk.

Objectives

This study examined the joint association of 2 gut microbiota metabolites, enterolactone and trimethylamine N-oxide (TMAO), that originate from intake of plant-based foods and animal products, respectively, in relation to CAD risk.

Methods

A prospective nested case-control study of CAD was conducted among participants who were free of diabetes, cardiovascular disease, and cancer in the Nurses' Health Study II and the Health Professionals Follow-up Study. Plasma concentrations of enterolactone and TMAO, as well as choline

SUBMITTER: Liu G 

PROVIDER: S-EPMC8277432 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature