Which Prostate Cancers are Undetected by Multiparametric Magnetic Resonance Imaging in Men with Previous Prostate Biopsy? An Analysis from the PICTURE Study.

ABSTRACT:

Background

Multiparametric magnetic resonance imaging (mpMRI) has improved risk stratification for suspected prostate cancer in patients following prior biopsy. However, not all significant cancers are detected by mpMRI. The PICTURE study provides the ideal opportunity to investigate cancer undetected by mpMRI owing to the use of 5 mm transperineal template mapping (TTPM) biopsy.

Objective

To summarise attributes of cancers systematically undetected by mpMRI in patients with prior biopsy.

Design setting and participants

PICTURE was a paired-cohort confirmatory study in which men requiring repeat biopsy underwent mpMRI followed by TTPM biopsy.

Outcome measurements and statistical analysis

Attributes were compared between cancers detected and undetected by mpMRI

SUBMITTER: Norris JM 

PROVIDER: S-EPMC8277581 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature