The Shape of the Oral Glucose Tolerance Test-Glucose Response Curve in Islet Cell Antibody-Positive vs. -Negative Obese Youth Clinically Diagnosed with Type 2 Diabetes.

ABSTRACT:

Background

The oral glucose tolerance test (OGTT)-glucose response curves (GRCs; incessant increase, monophasic, and biphasic) reflect insulin sensitivity and β-cell function, being worse in the former and superior in the latter. Here, we examined if the OGTT-GRC pattern is worse in obese antibody (glutamic acid decarboxylase 65-kDa [GAD65] and insulinoma-associated protein-2 [IA-2])-positive (Ab⁺) vs. -negative (Ab^-) youth clinically diagnosed with type 2 diabetes (CDX-T2D).

Methods

Forty-seven obese youth, 15 Ab⁺ and 32 Ab^-, were divided into three OGTT-GRC groups: incessant increase, monophasic, and biphasic. The prevalence of OGTT-GRC, clamp-measured insulin sensitivity, and β-cell function was compared.

Results

Incessan

SUBMITTER: Kim JY 

PROVIDER: S-EPMC8277592 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature