Non-invasive Standardised Uptake Value for Verification of the Use of Previously Validated Reference Region for [¹⁸F]Flortaucipir and [¹⁸F]Florbetapir Brain PET Studies.

ABSTRACT:

Purpose

The simplified reference tissue model (SRTM) is commonly applied for the quantification of brain positron emission tomography (PET) studies, particularly because it avoids arterial cannulation. SRTM requires a validated reference region which is obtained by baseline-blocking or displacement studies. Once a reference region is validated, the use should be verified for each new subject. This verification normally requires volume of distribution (V_T) of a reference region. However, performing dynamic scanning and arterial sampling is not always possible, specifically in elderly subjects and in advanced disease stages. The aim of this study was to investigate the use of non-invasive standardised uptake value (SUV) approaches, in comparison to V_T, as a veri

SUBMITTER: de Vries BM 

PROVIDER: S-EPMC8277631 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature