Parametric Mapping for TSPO PET Imaging with Spectral Analysis Impulsive Response Function.

ABSTRACT:

Purpose

The aim of this study was to investigate the use of spectral analysis (SA) for voxel-wise analysis of TSPO PET imaging studies. TSPO PET quantification is methodologically complicated by the heterogeneity of TSPO expression and its cell-dependent modulation during neuroinflammatory response. Compartmental models to account for this complexity exist, but they are unreliable at the high noise typical of voxel data. On the contrary, SA is noise-robust for parametric mapping and provides useful information about tracer kinetics with a free compartmental structure.

Procedures

SA impulse response function (IRF) calculated at 90 min after tracer injection was used as main parameter of interest in 3 independent PET imaging studies to investigate its sensitivity to (1) a TSPO

SUBMITTER: Veronese M 

PROVIDER: S-EPMC8277653 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature