Effect of Shortening the Scan Duration on Quantitative Accuracy of [¹⁸F]Flortaucipir Studies.

ABSTRACT:

Purpose

Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [¹⁸F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [¹⁸F]flortaucipir on its quantitative accuracy.

Procedures

Two study cohorts with Alzheimer's disease (AD) patients and healthy controls (HC) were included. All subjects underwent a 130-min dynamic [¹⁸F]flortaucipir PET scan consisting of two parts (0-60/80-130 min) post-injection. Arterial sampling was acquired during scanning of the first cohort only. For the second cohort, a second PET scan was acquired within 1-4 weeks of the first PET scan to

SUBMITTER: Tuncel H 

PROVIDER: S-EPMC8277654 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature