Quantification of Myocardial Creatine and Triglyceride Content in the Human Heart: Precision and Accuracy of in vivo Proton Magnetic Resonance Spectroscopy.

ABSTRACT:

Background

Proton magnetic resonance spectroscopy (¹ H-MRS) of the human heart is deemed to be a quantitative method to investigate myocardial metabolite content, but thorough validations of in vivo measurements against invasive techniques are lacking.

Purpose

To determine measurement precision and accuracy for quantifications of myocardial total creatine and triglyceride content with localized ¹ H-MRS.

Study type

Test-retest repeatability and measurement validation study.

Subjects

Sixteen volunteers and 22 patients scheduled for open-heart aortic valve replacement or septal myectomy.

Field strength/sequence

Prospectively ECG-triggered respiratory-gated free-breathing single-voxel point-resolved spectroscopy (PRESS) sequence at 3 T.

SUBMITTER: Bakermans AJ 

PROVIDER: S-EPMC8277665 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature