Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments.

ABSTRACT: Chemotherapy-induced cognitive impairment (CICI) is often reported as a neurotoxic side effect of chemotherapy. Although CICI has emerged as a significant medical problem, meaningful treatments are not currently available due to a lack of mechanistic understanding underlying CICI pathophysiology. Using the platinum-based chemotherapy cisplatin as a model for CICI, we show here that cisplatin suppresses nicotinamide adenine dinucleotide (NAD⁺) levels in the adult female mouse brain in vivo and in human cortical neurons derived from induced pluripotent stem cells in vitro. Increasing NAD⁺ levels through nicotinamide mononucleotide (NMN) administration prevented cisplatin-induced abnormalities in neural progenitor proliferation, neuronal morphogenesis, and

SUBMITTER: Yoo KH 

PROVIDER: S-EPMC8277702 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature