Performance of Eosinophil Cationic Protein as a Biomarker in Asthmatic Children.

ABSTRACT:

Background

Although blood eosinophils are a frequently used marker of type 2 inflammation in children with asthma, their sensitivity is relatively poor. Additional markers of type 2 inflammation are needed.

Objective

We hypothesized that plasma concentrations of eosinophil cationic protein (ECP), a marker of eosinophil activation, would be useful for detection of type 2 inflammation and would predict poorer asthma outcomes over 1 year.

Methods

Children and adolescents 6 through 17 years (N = 256) with confirmed asthma completed a baseline visit and a follow-up visit at 12 months. A subset also underwent systemic corticosteroid responsiveness testing with intramuscular triamcinolone. Outcome measures at 12 months included uncontrolled asthma, lung function, and asthma

SUBMITTER: Shah SN 

PROVIDER: S-EPMC8277708 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature