The roles of borderline personality disorder symptoms and dispositional capability for suicide in suicidal ideation and suicide attempts: Examination of the COMT Val158Met polymorphism.

ABSTRACT: There is a need to identify the subset of individuals with borderline personality disorder (BPD) symptoms at greatest risk for transitioning from suicidal ideation to a suicide attempt. Contemporary models of suicide risk propose that the capability for suicide is necessary for moving from suicidal ideation to a suicide attempt. Few studies have examined dispositional capability factors for suicide, especially among individuals with BPD symptoms. One candidate may be the catechol-o-methyltransferase (COMT) Val¹⁵⁸Met polymorphism given its influence on pain sensitivity and fear. This study examined the interactive relation of BPD symptoms and the COMT Val¹⁵⁸Met polymorphism to suicidal ideation and suicide attempts. Fifty-nine treatment-seeking patients were recruited.

SUBMITTER: Tull MT 

PROVIDER: S-EPMC8277722 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature