Ontology highlight
ABSTRACT:
SUBMITTER: Ismael S
PROVIDER: S-EPMC8277763 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Ismael Saifudeen S Nasoohi Sanaz S Li Lexiao L Aslam Khurram S KS Khan Mohammad Moshahid MM El-Remessy Azza B AB McDonald Michael P MP Liao Francesca-Fang FF Ishrat Tauheed T
Neurobiology of disease 20210521
Immune system hypersensitivity is believed to contribute to mental frailty in the elderly. Solid evidence indicates NOD-like receptor pyrin domain containing-3 (NLRP3)-inflammasome activation intimately connects aging-associated chronic inflammation (inflammaging) to senile cognitive decline. Thioredoxin interacting protein (TXNIP), an inducible protein involved in oxidative stress, is essential for NLRP3 inflammasome activity. This study aims to find whether TXNIP/NLRP3 inflammasome pathway is ...[more]