Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma.

ABSTRACT: Airway smooth muscle (ASM) is known for its role in asthma exacerbations characterized by acute bronchoconstriction and remodeling. The molecular mechanisms underlying multiple gene interactions regulating gene expression in asthma remain elusive. Herein, we explored the regulatory relationship between ASM genes to uncover the putative mechanism underlying asthma in humans. To this end, the gene expression from human ASM was measured with RNA-Seq in non-asthmatic and asthmatic groups. The gene network for the asthmatic and non-asthmatic group was constructed by prioritizing differentially expressed genes (DEGs) (121) and transcription factors (TFs) (116). Furthermore, we identified differentially connected or co-expressed genes in each group. The asthmatic group showed a loss of gene conne

SUBMITTER: Banerjee P 

PROVIDER: S-EPMC8277837 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature