The immunoregulatory function of peripheral blood CD71⁺ erythroid cells in systemic-onset juvenile idiopathic arthritis.

ABSTRACT: CD71⁺ erythroid cells (CECs) are recognized to have an immunoregulatory function via direct cell-cell interaction and soluble mediators. Circulating CECs appear in newborns or patients with hemolytic and cardiopulmonary disorders. To assess the biological role of CECs in systemic inflammation, we studied the gene expression and function in systemic-onset juvenile idiopathic arthritis (SoJIA). Peripheral blood mononuclear cells of SoJIA patients expressed upregulated erythropoiesis-related genes. It represented the largest expansion of CECs during active phase SoJIA among other inflammatory diseases. Despite the opposing roles of erythropoietin and hepcidin in erythropoiesis, both serum levels were in concert with the amounts of SoJIA-driven CECs. Circulating CECs counts in infla

SUBMITTER: Kanemasa H 

PROVIDER: S-EPMC8277864 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature