Paired maternal and fetal metabolomics reveal a differential fingerprint in preeclampsia versus fetal growth restriction.

ABSTRACT: Preeclampsia (PE) and fetal growth restriction (FGR) are both placenta-mediated disorders with unclear pathogenesis. Metabolomics of maternal and fetal pairs might help in understanding these disorders. We recruited prospectively pregnancies with normotensive FGR, PE without FGR, PE + FGR and uncomplicated pregnancies as controls. Nuclear magnetic resonance metabolomics were applied on plasma samples collected at delivery. Advanced lipoprotein, glycoprotein and choline profiling was performed using the Liposcale test. The software package Dolphin was used to quantify 24 low-molecular-weight metabolites. Statistical analysis comprised the comparison between each group of complicated pregnancies versus controls, considering 5% false discovery rate correction. Lipid profiles were altered in a

SUBMITTER: Youssef L 

PROVIDER: S-EPMC8277896 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature