Comprehensive Analysis of the Immune Infiltrates and PD-L1 of m⁶A RNA Methylation Regulators in Hepatocellular Carcinoma.

ABSTRACT: Recently, N ⁶-methyladenosine (m⁶A) RNA methylation in eukaryotic mRNA has become increasingly obvious in the pathogenesis and prognosis of cancer. Moreover, tumor microenvironment is involved in the regulation of tumorigenesis. In our research, the clinical data, including 374 tumor and 50 normal patients, were obtained from The Cancer Genome Atlas (TCGA). Then 19 m⁶A regulators were selected from other studies. Hepatocellular carcinoma (HCC) patients were clustered in cluster1/2, according to the consensus clustering for the m⁶A RNA regulators. We found that m⁶A regulators were upregulated in cluster1. The cluster1 was associated with higher programmed death ligand 1 (PD-L1) expression level, higher immunoscore, worse prognosi

SUBMITTER: Xu Y 

PROVIDER: S-EPMC8277965 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature