Sex differences in neuroimmune and glial mechanisms of pain.

ABSTRACT:

Abstract

Pain is the primary motivation for seeking medical care. Although pain may subside as inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain state can occur with significant regularity. Chronic pain requires aggressive management to minimize its physiological consequences and diminish its impact on quality of life. Although opioids commonly are prescribed for intractable pain, concerns regarding reduced efficacy, as well as risks of tolerance and dependence, misuse, diversion, and overdose mortality rates limit their utility. Advances in development of nonopioid interventions hinge on our appreciation of underlying mechanisms of pain hypersensitivity. For instance, the contributory role of immunity and the associated presence of a

SUBMITTER: Gregus AM 

PROVIDER: S-EPMC8277970 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature