Ontology highlight
ABSTRACT:
SUBMITTER: de Freitas Chama LL
PROVIDER: S-EPMC8278072 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
de Freitas Chama Laura L LL Ebstein Frédéric F Wiesrecker Birthe B Wagh Preshit R PR Hammer Elke E Weiss Frank U FU Junker Heike H Studencka-Turski Maja M Lerch Markus M MM Krüger Elke E Sendler Matthias M
Journal of cellular and molecular medicine 20210615 14
Uncovering potential new targets involved in pancreatitis may permit the development of new therapies and improvement of patient's outcome. Acute pancreatitis is a primarily sterile disease characterized by a severe systemic inflammatory response associated with extensive necrosis and a mortality rate of up to 24%. Considering that one of the reported disease mechanisms comprises the endoplasmic reticulum (ER) stress response and that the immunoproteasome is a key regulator to prevent proteotoxi ...[more]