Ontology highlight
ABSTRACT:
SUBMITTER: Chen Y
PROVIDER: S-EPMC8278087 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Chen Yongxia Y Jia Yunlu Y Mao Misha M Gu Yifeng Y Xu Chenpu C Yang Jingjing J Hu Wenxian W Shen Jun J Hu Dengdi D Chen Cong C Li Zhaoqing Z Chen Lini L Ruan Jian J Shen Peng P Zhou Jichun J Wei Qun Q Wang Linbo L
Journal of cellular and molecular medicine 20210611 14
Adriamycin (ADM) is currently one of the most effective chemotherapeutic agents in breast cancer treatment. However, growing resistance to ADM could lead to treatment failure and poor outcome. PLAC8 was reported as a novel highly conserved protein and functioned as an oncogene or tumour suppressor in various tumours. Here, we found higher PLAC8 expression was correlated with worse outcome and aggressive phenotype in breast cancer. Breast cancer patients with higher PLAC8 expression showed potent ...[more]