A novel ferroptosis phenotype-related clinical-molecular prognostic signature for hepatocellular carcinoma.

ABSTRACT: Ferroptosis is a newly identified cell death mechanism and potential biomarker for hepatocellular carcinoma (HCC) therapy; however, its clinical relevance and underlying mechanism remain unclear. In this study, transcriptome and methylome data from 374 HCC cases were investigated for 41 ferroptosis-related genes to identify ferroptosis activity-associated subtypes. These subtypes were further investigated for associations with clinical and pathological variables, gene mutation landscapes, deregulated pathways and tumour microenvironmental immunity. A gene expression signature and predictive model were developed and validated using an additional 232 HCC cases from another independent cohort. Two distinct ferroptosis phenotypes (Ferroptosis-H and Ferroptosis-L) were identified according to f

SUBMITTER: Deng T 

PROVIDER: S-EPMC8278110 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature