Mapping working memory-specific dysfunction using a transdiagnostic approach.

ABSTRACT:

Background

Working memory (WM) is an executive ability that allows one to hold and manipulate information for a short period of time. Schizophrenia and mood disorders are severe psychiatric conditions with overlapping genetic and clinical symptoms. Whilst WM has been suggested as meeting the criteria for being an endophenotype for schizophrenia and mood disorders, it still unclear whether they share overlapping neural circuitry.

Objective

The n-back task has been widely used to measure WM capacity, such as maintenance, flexible updating, and interference control. Here we compiled studies that included psychiatric populations, i.e., schizophrenia, bipolar disorder and major depressive disorder.

Methods

We performed a coordinate-based meta-analysis that combined 34 BOLD

SUBMITTER: Yaple ZA 

PROVIDER: S-EPMC8278205 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature