The Structure of a Peptide-Loaded Shark MHC Class I Molecule Reveals Features of the Binding between β₂-Microglobulin and H Chain Conserved in Evolution.

ABSTRACT: Cartilaginous fish are the most primitive extant species with MHC molecules. Using the nurse shark, the current study is, to the best of our knowledge, the first to present a peptide-loaded MHC class I (pMHC-I) structure for this class of animals. The overall structure was found to be similar between cartilaginous fish and bony animals, showing remarkable conservation of interactions between the three pMHC-I components H chain, β₂-microglobulin (β₂-m), and peptide ligand. In most previous studies, relatively little attention was given to the details of binding between the H chain and β₂-m, and our study provides important new insights. A pronounced conserved feature involves the insertion of a large β₂-m F56+W60 hydrophobic knob into a pleat of t

SUBMITTER: Wu Y 

PROVIDER: S-EPMC8278274 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature