Osteogenesis imperfecta tooth level phenotype analysis: Cross-sectional study.

ABSTRACT:

Introduction

Dental anomalies in Osteogenesis imperfecta (OI), such as tooth discoloration, pulp obliteration (calcified dental pulp space), and taurodontism (enlarged dental pulp space) vary between and within patients. To better understand the associations and variations in these anomalies, a cross-sectional study was designed to analyze the dental phenotype in OI patients at the individual tooth type.

Method

A cohort of 171 individuals with OI type I, III and IV, aged 3-55 years, were recruited and evaluated for tooth discoloration, pulp obliteration, and taurodontism at the individual tooth level, using intraoral photographs and panoramic radiographs.

Results

Genetic variants were identified in 154 of the participants. Patients with Helical α1 and α2 glycine subst

SUBMITTER: Taqi D 

PROVIDER: S-EPMC8278321 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature