Ontology highlight
ABSTRACT:
SUBMITTER: Weis-Banke SE
PROVIDER: S-EPMC8278322 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Weis-Banke Stine E SE Lerdrup Mads M Kleine-Kohlbrecher Daniela D Mohammad Faizaan F Sidoli Simone S Jensen Ole N ON Yanase Toshihiko T Nakamura Tomoko T Iwase Akira A Stylianou Anthe A Abu-Rustum Nadeem R NR Aghajanian Carol C Soslow Robert R Da Cruz Paula Arnaud A Koche Richard P RP Weigelt Britta B Christensen Jesper J Helin Kristian K Cloos Paul A C PAC
Cancer research 20200708 17
The mutant protein FOXL2<sup>C134W</sup> is expressed in at least 95% of adult-type ovarian granulosa cell tumors (AGCT) and is considered to be a driver of oncogenesis in this disease. However, the molecular mechanism by which FOXL2<sup>C134W</sup> contributes to tumorigenesis is not known. Here, we show that mutant FOXL2<sup>C134W</sup> acquires the ability to bind SMAD4, forming a FOXL2<sup>C134W</sup>/SMAD4/SMAD2/3 complex that binds a novel hybrid DNA motif AGHCAHAA, unique to the FOXL2<sup ...[more]