Tumor-Treating Fields for the treatment of glioblastoma: a systematic review and meta-analysis.

ABSTRACT:

Background

Tumor-Treating Fields (TTFields) is an emerging treatment modality for glioblastoma (GBM). Studies have shown a good safety profile alongside improved efficacy in newly diagnosed GBM (ndGBM), while a less clear effect was shown for recurrent GBM (rGBM). Despite regulatory support, sectors of the neuro-oncology community have been reluctant to accept it as part of the standard treatment protocol. To establish an objective understanding of TTFields' mechanism of action, safety, efficacy, and economical implications, we conducted a systematic literature review and meta-analysis.

Methods

A systematic search was conducted in PubMed, Scopus, and Cochrane databases. Twenty studies met the pre-defined inclusion criteria, incorporating 1636 patients (542 ndGBM and 1094 rGB

SUBMITTER: Regev O 

PROVIDER: S-EPMC8278345 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature