Myeloid phenotypes in severe COVID-19 predict secondary infection and mortality: a pilot study.

ABSTRACT:

Background

De-regulated host response to severe coronavirus disease 2019 (COVID-19), directly referring to the concept of sepsis-associated immunological dysregulation, seems to be a strong signature of severe COVID-19. Myeloid cells phenotyping is well recognized to diagnose critical illness-induced immunodepression in sepsis and has not been well characterized in COVID-19. The aim of this study is to review phenotypic characteristics of myeloid cells and evaluate their relations with the occurrence of secondary infection and mortality in patients with COVID-19 admitted in an intensive care unit.

Methods

Retrospective analysis of the circulating myeloid cells phenotypes of adult COVID-19 critically ill patients. Phenotyping circulating immune cells was performed by flow cyt

SUBMITTER: Marais C 

PROVIDER: S-EPMC8278374 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature