Time-Resolved Cryo-TEM Study on the Formation of Iron Hydroxides in a Collagen Matrix.

ABSTRACT: The mineralization of collagen via synthetic procedures has been extensively investigated for hydroxyapatite as well as for silica and calcium carbonate. From a fundamental point of view, it is interesting to investigate whether collagen could serve as a generic mineralization template for other minerals, like iron oxides. Here, bio-inspired coprecipitation reaction, generally leading to the formation of magnetite, is used to mineralize collagen with iron hydroxides. Platelet-shaped green rust crystals form outside the collagen matrix, while inside the collagen, nanoparticles with a size of 2.6 nm are formed, which are hypothesized to be iron (III) hydroxide. Mineralization with nanoparticles inside the collagen solely occurs in the presence of poly(aspartic acid) (pAsp). In the absence of

SUBMITTER: Oosterlaken BM 

PROVIDER: S-EPMC8278378 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature