Mitochondrial dysfunction: A hidden trigger of autism?

ABSTRACT: Autism is a heterogeneous neurodevelopmental and neuropsychiatric disorder with no precise etiology. Deficits in cognitive functions uncover at early stages and are known to have an environmental and genetic basis. Since autism is multifaceted and also linked with other comorbidities associated with various organs, there is a possibility that there may be a fundamental cellular process responsible for this. These reasons place mitochondria at the point of interest as it is involved in multiple cellular processes predominantly involving metabolism. Mitochondria encoded genes were taken into consideration lately because it is inherited maternally, has its own genome and also functions the time of embryo development. Various researches have linked mitochondrial mishaps like oxidative stress,

SUBMITTER: Balachandar V 

PROVIDER: S-EPMC8278534 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature